Maria Sirenko, Soobeom Lee, Zhengxi Sun, Ronan Chaligne, Sanam Loghavi, Georgios Asimomitis, Charlotte K. Brierley, Elsa Bernard, Sheng F. Cai, Robert M. Myers, Bettina Nadorp, Junya Sango, Morgan Lallo, Max F. Levine, Dylan Domenico, Juan E. Arango Ossa, Juan S. Medina-Martinez, Kamal Menghrajani, Audrey Lasry, Alice S. Mims, Helee Desai, Andrea Laganson, Chris Famulare, Minal Patel, Gerard Lozanski, Kelly L. Bolton, Aaron D. Viny, Mikhail Roshal, Ross L. Levine, Eirini P. Papapetrou, Eytan M. Stein, Dan A. Landau, Ann-Kathrin Eisfeld, Iannis Aifantis, Elli Papaemmanuil. Deconvoluting clonal and cellular architecture in IDH-mutant acute myeloid leukemia. Cell Stem Cell. 2025 Jul 3;32(7):1102-1121.e5. doi: 10.1016/j.stem.2025.04.012. Epub 2025 May 22. PMID: 40409258

Giovanni Gambi, Francesco Boccalatte, Javier Rodriguez Hernaez, Ziyan Lin, Bettina Nadorp, Alexander Polyzos, Jimin Tan, Kleopatra Avrampou, Giorgio Inghirami, Alex Kentsis, Effie Apostolou, Iannis Aifantis, Aristotelis Tsirigos. 3D chromatin hubs as regulatory units of identity and survival in human acute leukemia. Mol Cell. 2025 Jan 2;85(1):42-60.e7. doi: 10.1016/j.molcel.2024.11.040. Epub 2024 Dec 23. PMID: 39719705 PMCID: PMC11934262

Juan Carlos Balandrán , Iannis Aifantis . Blood. 2025 Jan 2;145(1):7-8. doi: 10.1182/blood.2024026887. Vitamin C deprivation puts stem cells to sleep. PMID: 39745692

Wang Q, Boccalatte F, Xu J, Gambi G, Nadorp B, Akter F, Mullin C, Melnick AF, Choe E, McCarter AC, Jerome NA, Chen S, Lin K, Khan S, Kodgule R, Sussman JH, Pölönen P, Rodriguez-Hernaez J, Narang S, Avrampou K, King B, Tsirigos A, Ryan RJH, Mullighan CG, Teachey DT, Tan K, Aifantis I, and Chiang M. Native stem cell transcriptional circuits define cardinal features of high-risk leukemia. The Journal of Experimental Medicine. 2025 Apr 7;222(4):e20231349. doi: 10.1084/jem.20231349. PMID: 39969525; PMCID: PMC11837855.

Ciantra Z, Paraskevopoulou V, and Aifantis I. The rewired immune microenvironment in leukemia. 2025 Mar;26(3):351-365. doi: 10.1038/s41590-025-02096-9. PMID: 40021898.

Kathryn Hockemeyer, Theodore Sakellaropoulos, Xufeng Chen, Olha Ivashkiv, Maria Sirenko, Hua Zhou, Giovanni Gambi, Elena Battistello, Kleopatra Avrampou, Zhengxi Sun, Maria Guillamot, Luis Chiriboga, George Jour, Igor Dolgalev, Kate Corrigan, Kamala Bhatt, Iman Osman, Aristotelis Tsirigos, Nikos Kourtis, Iannis Aifantis. The stress response regulator HSF1 modulates natural killer cell anti-tumour immunity. Nature Cell Biology. 2024 Oct;26(10):1734-1744. doi: 10.1038/s41556-024-01490-z. Epub 2024 Sep 2. PMID: 39223375.

Sonali Narang, Yohana Ghebrechristos, Nikki A Evensen, Nina Murrell, Sylwia Jasinski, Talia H Ostrow, David T Teachey, Elizabeth A Raetz, Timothee Lionnet, Matthew Witkowski, Iannis Aifantis, Aristotelis Tsirigos, William L Carroll. Clonal evolution of the 3D chromatin landscape in patients with relapsed pediatric B-cell acute lymphoblastic leukemia. Nature Communications. 2024 Aug 28;15(1):7425. doi: 10.1038/s41467-024-51492-6. PMID: 39198446.

Jimin Tan, Nina Shenker-Tauris, Javier Rodriguez-Hernaez, Eric Wang, Theodore Sakellaropoulos, Francesco Boccalatte, Palaniraja Thandapani, Jane Skok, Iannis Aifantis, David Fenyö, Bo Xia, Aristotelis Tsirigos. Cell-type-specific prediction of 3D chromatin organization enables high-throughput in silico genetic screening. Nature Biotechnology. 2023 Aug;41(8):1140-1150. doi: 10.1038/s41587-022-01612-8. Epub 2023 Jan 9. PMID: 36624151.

Chen X, Lu Q, Zhou H, Liu J, Nadorp B, Lasry A, Sun Z, Lai B, Rona G, Zhang J, Cammer M, Wang K, Al-Santli W, Ciantra Z, Guo Q, You J, Sengupta D, Boukhris A, Zhang H, Liu C, Cresswell P, Dahia PLM, Pagano M, Aifantis I*, Wang J*. A membrane-associated MHC-I inhibitory axis for cancer immune evasion. Cell. 2023 Aug 31;186(18):3903-3920.e21. PMID: 37557169.

Palaniraja Thandapani, Andreas Kloetgen, Matthew T. Witkowski, Christina Glytsou, Anna K. Lee, Eric Wang, Jingjing Wang, Sarah E. LeBoeuf, Kleopatra Avrampou, Thales Papagiannakopoulos, Aristotelis Tsirigos & Iannis Aifantis. Nature. 2022. VOLUME 601, ISSUE 7893, January 20th, 2022

Eric Wang, Hua Zhou, Bettina Nadorp, Geraldine Cayanan, Xufeng Chen, Anna H. Yeaton, Sofia Nomikou, Matthew T. Witkowski, Sonali Narang, Andreas Kloetgen, Palaniraja Thandapani, Niklas Ravn-Boess, Aristotelis Tsirigos, Iannis Aifantis. Cell Press. 2021. VOLUME 28, ISSUE 4, P718-731.E6, APRIL 01, 2021

Witkowski MT*, Dolgalev I*, Evensen NA, et al. Extensive Remodeling of the Immune Microenvironment in B Cell Acute Lymphoblastic Leukemia [published online ahead of print, 2020 May 14]. Cancer Cell. 2020;S1535-6108(20)30214-2. doi:10.1016/j.ccell.2020.04.015

*Equal contribution

Kloetgen A*, Thandapani P*, Ntziachristos P*, Ghebrechristos Y, Nomikou S, Lazaris C, Chen X, Hu H, Bakogianni S, Wang J, Fu Y, Boccalatte F, Zhong H, Paietta E, Trimarchi T, Zhu Y, Van Vlierberghe P, Inghirami GG, Lionnet T, Aifantis I, Tsirigos A. Three-dimensional chromatin landscapes in T cell acute lymphoblastic leukemia. Nat Genet. 2020 Apr;52(4):388-400. doi: 10.1038/s41588-020-0602-9. Epub 2020 Mar 23. PubMed PMID: 32203470; PubMed Central PMCID: PMC7138649.

*Equal contribution

Lazaris C, Aifantis I, Tsirigos A. On Epigenetic Plasticity and Genome Topology. Trends Cancer. 2020 Mar;6(3):177-180. doi: 10.1016/j.trecan.2020.01.006. Epub 2020 Feb 7. PubMed PMID: 32101721.

Witkowski MT, Kousteni S, Aifantis I. Mapping and targeting of the leukemic microenvironment. J Exp Med. 2020 Feb 3;217(2). pii: e20190589. doi:
10.1084/jem.20190589. PubMed PMID: 31873722; PubMed Central PMCID: PMC7041707.

Witkowski MT, Lasry A, Carroll WL, Aifantis I. Immune-Based Therapies in Acute Leukemia. Trends Cancer. 2019 Oct;5(10):604-618. doi: 10.1016/j.trecan.2019.07.009. Epub 2019 Aug 29. Review. PubMed PMID: 31706508; PubMed Central PMCID: PMC6859901.

Kloetgen A*, Thandapani P*, Tsirigos A, Aifantis I. 3D Chromosomal Landscapes in Hematopoiesis and Immunity. Trends Immunol. 2019 Sep;40(9):809-824. doi:10.1016/j.it.2019.07.003. Epub 2019 Aug 15. Review. PubMed PMID: 31422902; PubMed Central PMCID: PMC6718347.

*Equal contribution

Chen X*, Glytsou C*, Zhou H, Narang S, Reyna DE, Lopez A, Sakellaropoulos T, Gong Y, Kloetgen A, Yap YS, Wang E, Gavathiotis E, Tsirigos A, Tibes R, Aifantis I.Targeting mitochondrial structure sensitizes acute myeloid leukemia to Venetoclax treatment. Cancer Discovery. 2019 May 2.

*Equal contribution

Guillamot M, Ouazia D, Dolgalev I, Yeung ST, Kourtis N, Dai Y, Corrigan K, Zea-Redondo L, Saraf A, Florens L, Washburn MP, Tikhonova AN, Malumbres M, Gong Y, Tsirigos A, Park C, Barbieri C, Khanna KM, Busino L, Aifantis I. The E3 ubiquitin ligase SPOP controls resolution of systemic inflammation by triggering MYD88 degradation. Nat Immunol. 2019 Sep;20(9):1196-1207. doi: 10.1038/s41590-019-0454-6. Epub 2019 Aug 12. PubMed PMID: 31406379.

Tikhonova AN*, Dolgalev I*, Hu H, Sivaraj KK, Hoxha E, Cuesta-Domínguez Á, Pinho S, Akhmetzyanova I, Gao J, Witkowski M, Guillamot M, Gutkin MC, Zhang Y, Marier C, Diefenbach C, Kousteni S, Heguy A, Zhong H, Fooksman DR, Butler JM, Economides A, Frenette PS, Adams RH, Satija R, Tsirigos A, Aifantis I.The bone marrow microenvironment at single-cell resolution.Nature. 2019 Apr 10. doi: 10.1038/s41586-019-1104-8.

*Equal contribution

Wang E*, Lu SX*, Pastore A*, Chen X, Imig J, Chun-Wei Lee S, Hockemeyer K, Ghebrechristos YE, Yoshimi A, Inoue D, Ki M, Cho H, Bitner L, Kloetgen A, Lin KT, Uehara T, Owa T, Tibes R, Krainer AR, Abdel-Wahab O, Aifantis I.Targeting an RNA-Binding Protein Network in Acute Myeloid Leukemia.Cancer Cell. 2019 Mar 18;35(3):369-384.e7.

*Equal contribution

Cancer Cell Issue Highlight Article (click here)

Nikos Kourtis*, Charalampos Lazaris*, Kathryn Hockemeyer, Juan Carlos Balandrán, Alejandra R. Jimenez, Jasper Mullenders, Yixiao Gong, Thomas Trimarchi, Kamala Bhatt, Hai Hu, Liza Shrestha, Alberto Ambesi-Impiombato, Michelle Kelliher, Elisabeth Paietta, Gabriela Chiosis, Monica L. Guzman, Adolfo A. Ferrando, Aristotelis Tsirigos & Iannis Aifantis. Oncogenic hijacking of the stress response machinery in T cell acute lymphoblastic leukemia. Nature Medicine 2018 Jul 23. DOI: 10.1038/s41591-018-0105-8

*Equal contribution

Luisa Cimmino, Benjamin G. Neel, Iannis Aifantis

(In Press, Trends in Cell Biology, available online April 30th 2018).

Yixiao Gong*, Charalampos Lazaris*, Theodore Sakellaropoulos, Aurelie Lozano, Prabhanjan Kambadur, Panagiotis Ntziachristos, Iannis Aifantis & Aristotelis Tsirigos. Stratification of TAD boundaries reveals preferential insulation of super-enhancers by strong boundaries. Nature Communications 9 (542). DOI:10.1038/s41467-018-03017-1 (published online February 7th 2018).

*Equal contribution

Cimmino L, Dolgalev I, Wang Y, Yoshimi A, Martin GH, Wang J, Ng V, Xia B, Witkowski MT, Mitchell-Flack M, Grillo I, Bakogianni S, Ndiaye-Lobry D, Martín MT, Guillamot M, Banh RS, Xu M, Figueroa ME, Dickins RA, Abdel-Wahab O, Park CY, Tsirigos A, Neel BG, Aifantis I. Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression. Cell. 2017 Aug 16 DOI: 10.1016/j.cell.2017.07.032, PMID: 28823558

Alexandros Strikoudis, Charalampos Lazaris, Panagiotis Ntziachristos, Aristotelis Tsirigos and Iannis Aifantis. Opposing functions of H2BK120 ubiquitylation and H3K79 methylation in the regulation of pluripotency by the Paf1 complex. Cell Cycle 2017, 10.1080/15384101.2017.1295194.

Charalampos Lazaris, Stephen Kelly, Panagiotis Ntziachristos, Iannis Aifantis & Aristotelis Tsirigos. HiC-bench: comprehensive and reproducible Hi-C data analysis designed for parameter exploration and benchmarking. BMC Genomics 2017 18:22. doi: 10.1186/s12864-016-3387-6

Beatriz Aranda-Orgilles, Ricardo Saldaña-Meyer, Eric Wang, Eirini Trompouki, Anne Fassl, Stephanie Lau, Jasper Mullenders, Pedro P. Rocha, Ramya Raviram, María Guillamot, María Sánchez-Díaz, Kun Wang, Clarisse Kayembe, Nan Zhang, Leonela Amoasii, Avik Choudhuri, Jane A. Skok, Markus Schober, Danny Reinberg, Piotr Sicinski, Heinrich Schrewe, et al.
Cell Stem Cell, Volume 19, Issue 6, 1 December 2016, Pages 784-799

Alexandros Strikoudis, Charalampos Lazaris, Thomas Trimarchi, Antonio L. Galvao Neto, Yan Yang, Panagiotis Ntziachristos, Scott Rothbart, Shannon Buckley, Igor Dolgalev, Matthias Stadtfeld, Brian D. Strahl, Brian D. Dynlacht, Aristotelis Tsirigos & Iannis Aifantis. Regulation of transcriptional elongation in pluripotency and cell differentiation by the PHD-finger protein Phf5a. Nature Cell Biology 18, 1127–1138 (2016) doi:10.1038/ncb3424.

Bryan King, Francesco Boccalatte, Kelly Moran-Crusio, Elmar Wolf, Jingjing Wang, Clarisse Kayembe, Charalampos Lazaris, Xiaofeng Yu, Beatriz Aranda-Orgilles, Anna Lasorella & Iannis Aifantis. The ubiquitin ligase Huwe1 regulates the maintenance and lymphoid commitment of hematopoietic stem cells. Nature Immunology 17, 1312–1321 (2016) doi:10.1038/ni.3559.

Ntziachristos P, Abdel-Wahab O, Aifantis I.: Emerging concepts of epigenetic dysregulation in hematological malignancies. Nature Immunology 2016, 01 August.

Guillamot M, Cimmino L, Aifantis I: The Impact of DNA Methylation in Hematopoietic Malignancies. Trends in Cancer 2016, 2:70–83.

N. Kourtis, A. Strikoudis, and I. Aifantis, “Emerging roles for the FBXW7 ubiquitin ligase in leukemia and beyond,”
Current Opinion in Cell Biology, vol. 37, pp. 28–34, Dec. 2015.

Gao J, Buckley SM, Cimmino L, Guillamot M, Strikoudis A, Cang Y, Goff SP, Aifantis I. The CUL4-DDB1 ubiquitin ligase complex controls adult and embryonic stem cell differentiation and homeostasis.
Elife. 2015 Nov 27;4. pii: e07539. doi: 10.7554/eLife.07539. PMID: 26613412

Jasper Mullenders, Beatriz Aranda-Orgilles, Priscillia Lhoumaud, Matthew Keller, Juhee Pae, Kun Wang, Clarisse Kayembe, Pedro P. Rocha, Ramya Raviram, Yixiao Gong, Prem K. Premsrirut, Aristotelis Tsirigos, Richard Bonneau, Jane A. Skok, Luisa Cimmino, Daniela Hoehn and Iannis Aifantis. Cohesin loss alters adult hematopoietic stem cell homeostasis, leading to myeloproliferative neoplasms.
JEM 212(11):1833-1850, doi: 10.1084/jem.20151323.

Pitt LA, Tikhonova AN, Hu H, Trimarchi T, King B, Gong Y, Sanchez-Martin M, Tsirigos A, Littman DR, Ferrando AA, Morrison SJ, Fooksman DR, Aifantis I, Schwab SR. CXCL12-Producing Vascular Endothelial Niches Control Acute T Cell Leukemia Maintenance.
Cancer Cell. 2015 Jun 8;27(6):755-68. doi: 10.1016/j.ccell.2015.05.002. PubMed PMID: 26058075.

Cimmino L, Dawlaty MM, Ndiaye-Lobry D, Yap YS, Bakogianni S, Yu Y, Bhattacharyya S, Shaknovich R, Geng H, Lobry C, Mullenders J, King B, Trimarchi T, Aranda-Orgilles B, Liu C, Shen S, Verma AK, Jaenisch R, Aifantis I. TET1 is a tumor suppressor of hematopoietic malignancy. Nat Immunol. 2015 Jun;16(6):653-62. doi: 10.1038/ni.3148. Epub 2015 Apr 13.
PubMed PMID: 25867473.

Nikos Kourtis, Rana S. Moubarak, Beatriz Aranda-Orgilles, Kevin Lui, Iraz T. Aydin, Thomas Trimarchi, Farbod Darvishian, Christine Salvaggio, Judy Zhong, Kamala Bhatt, Emily I. Chen, Julide T. Celebi, Charalampos Lazaris, Aristotelis Tsirigos, Iman Osman, Eva Hernando & Iannis Aifantis

Nature Cell Biology 17, 322–332 (2015) | doi:10.1038/ncb3121

Panagiotis Ntziachristos, Aristotelis Tsirigos, G. Grant Welstead, Thomas Trimarchi, Sofia Bakogianni, Luyao Xu, Evangelia Loizou, Linda Holmfeldt, Alexandros Strikoudis, Bryan King, Jasper Mullenders, Jared Becksfort, Jelena Nedjic, Elisabeth Paietta, Martin S. Tallman, Jacob M. Rowe, Giovanni Tonon, Takashi Satoh, Laurens Kruidenier, Rab Prinjha, Shizuo Akira, Pieter Van Vlierberghe, Adolfo A. Ferrando, Rudolf Jaenisch, Charles G. Mullighan & Iannis Aifantis.
Nature. 2014 Aug 17

Trimarchi T, Bilal E, Ntziachristos P, Fabbri G, Dalla-Favera R, Tsirigos A, Aifantis I.
Cell. 2014 Jul 31

Strikoudis A, Guillamot M, Aifantis I.
EMBO Rep. 2014

Ntziachristos P, Lim JS, Sage J, Aifantis I.
Cancer Cell. 2014 Mar 17

Lobry C, Oh P, Mansour MR, Look AT, Aifantis I.
Blood. 2014 Apr 17

Abdel-Wahab O, Gao J, Adli M, Dey A, Trimarchi T, Chung YR, Kuscu C, Hricik T, Ndiaye-Lobry D, Lafave LM, Koche R, Shih AH, Guryanova OA, Kim E, Li S, Pandey S, Shin JY, Telis L, Liu J, Bhatt PK, Monette S, Zhao X, Mason CE, Park CY, Bernstein BE, Aifantis I, Levine RL.

J Exp Med. 2013 Nov 18

Chaumeil J, Micsinai M, Ntziachristos P, Roth DB, Aifantis I, Kluger Y, Deriano L, Skok JA.

Nat Commun. 2013

Trimarchi T, Ntziachristos P, Aifantis I.

Nat Genet. 2013 Aug

King B, Trimarchi T, Reavie L, Xu L, Mullenders J, Ntziachristos P, Aranda-Orgilles B, Perez-Garcia A, Shi J, Vakoc C, Sandy P, Shen SS, Ferrando A, Aifantis I.

Cell. 2013 Jun 20

Oh P, Lobry C, Gao J, Tikhonova A, Loizou E, Manent J, van Handel B, Ibrahim S, Greve J, Mikkola H, Artavanis-Tsakonas S, Aifantis I.

Cell Stem Cell. 2013 Aug 1

Ntziachristos P, Mullenders J, Trimarchi T, Aifantis I.

Adv Immunol. 2013

Reavie L, Buckley SM, Loizou E, Takeishi S, Aranda-Orgilles B, Ndiaye-Lobry D, Abdel-Wahab O, Ibrahim S, Nakayama KI, Aifantis I.

Cancer Cell. 2013 Mar 18

Chaumeil J, Micsinai M, Ntziachristos P, Deriano L, Wang JM, Ji Y, Nora EP, Rodesch MJ, Jeddeloh JA, Aifantis I, Kluger Y, Schatz DG, Skok JA.

Cell Rep. 2013 Feb 21

Guy CS, Vignali KM, Temirov J, Bettini ML, Overacre AE, Smeltzer M, Zhang H, Huppa JB, Tsai YH, Lobry C, Xie J, Dempsey PJ, Crawford HC, Aifantis I, Davis MM, Vignali DA.

Nat Immunol. 2013 Mar

Lobry C, Ntziachristos P, Ndiaye-Lobry D, Oh P, Cimmino L, Zhu N, Araldi E, Hu W, Freund J, Abdel-Wahab O, Ibrahim S, Skokos D, Armstrong SA, Levine RL, Park CY, Aifantis I.

J Exp Med. 2013 Feb 11

Cimmino L, Aifantis I.

Cancer Discov. 2012 Nov

Buckley SM, Aranda-Orgilles B, Strikoudis A, Apostolou E, Loizou E, Moran-Crusio K, Farnsworth CL, Koller AA, Dasgupta R, Silva JC, Stadtfeld M, Hochedlinger K, Chen EI, Aifantis I.

Cell Stem Cell. 2012 Dec 7

Tikhonova A, Aifantis I.

Immunity. 2012 Oct 19