Welcome to the Aifantis Lab
Our laboratory studies the molecular mechanisms driving normal stem cell differentiation and malignant transformation. More specifically, we are using the hematopoietic system as our model of study and focus on the genomic, epigenetic and proteomic regulation of hematopoietic stem cell differentiation and induction of leukemia and lymphoma. Our latest obsessions are diverse regulatory mechanisms including ubiquitin-regulated protein abundance, DNA and Histone methylation and the role of long non-coding RNAs in leukemia induction, progression and relapse after treatment. Finally, we are interested to visualize and measure the impact of tumor micro-environment on these regulatory mechanisms and test drugs that will target either the tumor or the tumor niche using both animal and human xenograft disease models.
Recent Publications
Cell (August 1 2023)
A membrane-associated MHC-I inhibitory axis for cancer immune evasion
Cancer Discover (July 1 2023)
Mitophagy Promotes Resistance to BH3 Mimetics in Acute Myeloid Leukemia
Molecular Cell (March 20 2023)
Stepwise activities of mSWI/SNF family chromatin remodeling complexes direct T cell activation and exhaustion
Nature Cancer (December 29 2022)
An inflammatory state remodels the immune microenvironment and improves risk stratification in acute myeloid leukemia
Cancer Discovery (October 1 2022)
The Impact of Inflammation-Induced Tumor Plasticity during Myeloid Transformation
Nature Immunology (September 22 2022)
NUDT21 limits CD19 levels through alternative mRNA polyadenylation in B cell acute lymphoblastic leukemia
Cell Stem Cell (February 3 2022)
TRAF6 functions as a tumor suppressor in myeloid malignancies by directly targeting MYC oncogenic activity
Nature (January 20 2022)
Valine tRNA levels and availability regulate complex I assembly in leukaemia
Cell Press (April 1 2021)
Surface antigen-guided CRISPR screens identify regulators of myeloid leukemia differentiation
Cancer Cell (June 8 2020)
Extensive Remodeling of the Immune Microenvironment in B Cell Acute Lymphoblastic Leukemia
Nature Genetics (March 23 2020)
Three-dimensional chromatin landscapes in T cell acute lymphoblastic leukemia
Trends in Cancer (February 7 2020)
On Epigenetic Plasticity and Genome Topology
Journal of Experimental Medicine (February 3 2020)
Mapping and targeting of the leukemic microenvironment
Trends in Cancer (August 29 2019)
Immune-Based Therapies in Acute Leukemia
Trends in Immunology (August 15 2019)
3D Chromosomal Landscapes in Hematopoiesis and Immunity
Nature Immunology (August 12 2019)
The E3 ubiquitin ligase SPOP controls resolution of systemic inflammation by triggering MYD88 degradation
Nature (May 9th 2019)
The bone marrow microenvironment at single-cell resolution
Cancer Discovery (May 2nd 2019)
Targeting mitochondrial structure sensitizes acute myeloid leukemia to Venetoclax treatment
Cancer Cell (March 18th 2019)
Targeting an RNA-Binding Protein Network in Acute Myeloid Leukemia
Nature Medicine (23 July 2018)
Oncogenic hijacking of the stress response machinery in T cell acute lymphoblastic leukemia
Trends in Cell Biology (30 April 2018)
Vitamin C in Stem Cell Reprogramming and Cancer
Nature Communications (February 2018)
Stratification of TAD boundaries reveals preferential insulation of super-enhancers by strong boundaries
Cell (September 2017)
Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression
Cancer Discovery (May 2017)
BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells
BMC Genomics (5th January 2017)
HiC-bench: comprehensive and reproducible Hi-C data analysis designed for parameter exploration and benchmarking