The Iannis Aifantis Lab

LAB PUBLICATIONS (2003-today)
“Aifantis I, Raetz E, Buonamici S. Molecular pathogenesis of T cell leukemia and lymphoma. Nature Reviews Immunology, 8 (5): 380-390, 2008.”
Thompson B, Jankovic V, Gao J, Buonamici S, Nimer S, and Aifantis I. The ubiquitin ligase Fbw7 as a regulator of hematopoietic stem cell self-renewal. J. Exp. Med..2008; 0: jem.20080277-14
Johnson K, Hashimshony T, Sawai C, Pongubala J, Skok J, Aifantis I, and Singh H. Convergent signaling pathways synergistically induce immunoglobulin light-chain recombination. Immunity. 2008 Mar;28(3):335-45. Epub 2008 Feb 14.
Thompson B, Buonamici S, Sulis M-L, Palomero T, Vilimas T, Basso G, Ferrando A, and Aifantis I. The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia. The Journal of Experimental Medicine, 204(8): 1825-1835. (2007).*(A “Preview”, by H. Bashyam, describing our findings appears in the same issue of The Journal of Experimental Medicine).
Aifantis I, Vilimas T, Buonamici S. Notches, NF-kBs and the making of T cell leukemia. Cell Cycle, 6(4): 403-6, 2007.
Vilimas T, Mascarenhas J, Palomero T, Mandal M, Buonamici S, Ferrando A, Miele L, Aifantis I. Targeting the NF-kB signaling pathway in Notch1-induced T cell leukemia. Nature Medicine, 13: 70-77, 2007.
Aifantis I, Bassing C, Garbe A, Sawai K, Alt F, von Boehmer H. The E enhancer controls the generation of DN -TCR expressing T cells that can give rise to different lineages of T cells. The Journal of Experimental Medicine, 203(6): 1543-50.
A. El Andaloussi, S. Graves, F. Meng, M. Mashayekhi, and I. Aifantis. The Hedgehog signaling network controls lymphoid progenitor differentiation in the thymus. Nature Immunology, 7(4):418-426. (2006).
A. Cooper, K. Sawai, S. Powers, E. Sicinska, P. Sicinski, M. Clark and I. Aifantis. Regulation of pre-B cell proliferation by Cyclin D3. Nature Immunology, 7: 489-497. (2006)
L. Scimone, I. Aifantis, I Apostolou, H. von Boehmer and U. von Andrian. A multi-step adhesion cascade for lymphoid progenitor homing to the thymus. PNAS, 103 (18): 7006-11. (2006).
E. Reschly, C.Spaulding, W.V. Graham, R.L. Brumbaugh, T. Vilimas, I. Aifantis, W.S. Pear, and B. Kee. Notch1 promotes survival of E2A-deficient T cell lymphomas through pre-T cell receptor dependent and independent mechanisms . BLOOD, 15;107(10):4115-21. (2006).
I. Aifantis, M. Mandal, K. Sawai and T. Vilimas. Regulation of T cell progenitor survival and cell cycle entry by the pre-T Cell Receptor. Immunological Reviews 209: 159-169 (2006).
P. Oberdoerffer, C. Kanellopoulou, V. Heissmeyer, C. Paeper, C. Borowski, I. Aifantis, A. Rao and K. Rajewsky. Efficiency of RNA interference in the mouse hematopoietic system varies between cell-types and developmental stages. Molecular and Cellular Biology 25, 3896-3905 (2005).
M. Mandal, C. Borowski, T. Palomero, A.A. Ferrando, P. Oberdoerffer, F. Meng, A. Ruiz-Vela, M. Ciofani, J-C. Zuniga-Pflucker, I. Screpanti, A. T. Look, S. J. Korsmeyer, K. Rajewsky, H. von Boehmer and I. Aifantis. The BCL2A1 gene, as a pre-TCR-induced regulator of thymocyte survival and T cell leukemia. The Journal of Experimental Medicine 4, 603-614 (2005). *(A “Preview”, by H. van Epps, describing our findings appears in the same issue of The Journal of Experimental Medicine).
M.R. Clark, A.B. Cooper, L.Wang, and I.Aifantis. The Pre-B cell receptor in B cell development: Recent advances, persistent questions and conserved mechanisms. In Molecular Analysis of B-Lymphocyte Development Springer Verlag,-Springer. Editors: R. Grosschedl and H. Singh. 87-104 (2005).
C. Borowski, X. Li, I. Aifantis, F. Gounari, and H. von Boehmer. Pre-TCR and TCR are not interchangeable partners of TCRß during T lymphocyte development. The Journal of Experimental Medicine 199, 607-615 (2004).
Sicinska E., Aifantis I., Le Cam L., Swat W. Borowski C., Yu Q. Ferrando A.A., Levin S.D., Geng Y., von Boehmer H. and Sicinski P. Requirements for cyclin D3 in lymphocyte development and leukemia. Cancer Cell 4, 451-61 (2003). *(A “Comment”, by J. Aster, describing our findings appears in the same issue of Cancer Cell).