"Our Lab became a part of the Howard Hughes Medical Institute"!.
- "In a paper in Nature our lab is identifying the chemokine receptor CCR7 as a signal for the infiltration of leukemic cells into the CNS."Click image to link to the paper
- "In a paper published this week in CELL Stem Cell Jie Studied the role of the Hedgehog signaling pathway in the differentiation of Hematopoietic Stem Cells."Click image to link to the paper
- “In a recent issue of PNAS Malay, Kelly and Suqing identify Bim and Bid as regulators of pre-T cell death”. Click image to link to the paper
- “Katie helped the Ferrando lab to study the cooperation of g-secretase inhibitors and glucocotricoids for the treatment of T-ALL”. Click image to link to the paper
- “In an article at The Journal of Experimental Medicine Ben Thompson identifies the E3 ubiquitin ligase Fbw7 as a novel regulator of stem cell quiescence and self-renewal”. Click image to link to the paper
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Research and Clinical Interests
Our laboratory studies the molecular mechanisms controlling hematopoietic stem cell (HSC) self-renewal, differentiation and transformation. More specifically we focus on the regulation of HSC cell cycle entry and on the effects of Notch signaling in stem cell differentiation. Finally, we study the role of the Notch pathway as an oncogenic trigger in acute lymphoblastic leukemia. Our goal is to design novel therapies that will target and suppress Notch transforming activity in vivo.