- “In an article at The Journal of Experimental Medicine Ben Thompson identifies the E3 ubiquitin ligase Fbw7 as a novel regulator of stem cell quiescence and self-renewal”. Click image to link to the paper
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Research and Clinical Interests
Our laboratory studies the molecular mechanisms controlling hematopoietic stem cell (HSC) self-renewal, differentiation and transformation. More specifically we focus on the regulation of HSC cell cycle entry and on the effects of Notch signaling in stem cell differentiation. Finally, we study the role of the Notch pathway as an oncogenic trigger in acute lymphoblastic leukemia. Our goal is to design novel therapies that will target and suppress Notch transforming activity in vivo.
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- “ Silvia and Iannis discuss molecular mechanisms of T cell leukemia in an article at Nature Reviews Immunology”. Click image to link to the paper