Research and Clinical Interests 18 May, 2010
Our laboratory studies the molecular mechanisms controlling hematopoietic stem cell (HSC) self-renewal, differentiation and transformation. More specifically we focus on the regulation of HSC cell cycle entry and on the effects of Notch signaling in stem cell differentiation. Finally, we study the role of the Notch pathway as an oncogenic trigger in acute lymphoblastic leukemia. Our goal is to design novel therapies that will target and suppress Notch transforming activity in vivo.
Cell Stem Cell. Regulation of pluripotency and cellular reprogramming by the ubiquitin-proteasome system.
Cancer Cell. Therapeutic targeting of the cyclin D3:CDK4/6 complex in T cell leukemia.
Cancer Cell. Bryan and Panos are discussing the role of the TLX proteins on T-cell differentiation and transformation.
Nature Medicine. February 1st, 2012. In a recent article at Nature Medicine, Panos studies the epigenetic landscapes of T cell acute lymphoblastic leukemia and identified the PRC2 complex as a novel tumor suppressor in this disease.
In a recent Cover Article at Cancer Cell, Kelly and Linsey identify TET2, an enzyme regulating DNA methylation, as a novel tumor suppressor and regulator of stem cell self-renewal.
In a recent issue of Nature, we identify a novel tumour-suppressor function for the Notch pathway in myeloid leukaemia
In a recent issue of Cancer Cell, we identify CYLD and IKK as essential for the maintenance of T-ALL
In a recent issue of Nature Immunology Jelena and Iannis discuss RNA-modifying proteins, Notch stability and T-cell leukemia.
In an article at The Journal of Experimental Medicine Ben Thompson identifies the E3 ubiquitin ligase Fbw7 as a novel regulator of stem cell quiescence and self-renewal.
In a paper in Nature Immunology, our lab has uncovered an interaction between Fbw7 and c-myc as an essential regulator of stem cell differentiation.
In a paper in Nature our lab identified the chemokine receptor CCR7 as a signal for the infiltration of leukemic cells into the CNS.
In a paper published this week in CELL Stem Cell, Jie studied the role of the Hedgehog signaling pathway in the differentiation of Hematopoietic Stem Cells.