Cell Stem Cell October 25, 2012

1-s2.0-S1934590912X00134-cov150hCell Stem Cell. Regulation of pluripotency and cellular reprogramming by the ubiquitin-proteasome system.
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Cancer Cell October 16, 2012

1-s2.0-S1535610812X00114-cov150hCancer Cell. Therapeutic targeting of the cyclin D3:CDK4/6 complex in T cell leukemia.View Details | PDF

Cancer Cell April 17, 2012

cancer_cell_21_4Cancer Cell. Bryan and Panos are discussing the role of the TLX proteins on T-cell differentiation and transformation.
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Nature Medicine February 1st, 2012

nature_feb2012Nature Medicine. February 1st, 2012. In a recent article at Nature Medicine, Panos studies the epigenetic landscapes of T cell acute lymphoblastic leukemia and identified the PRC2 complex as a novel tumor suppressor in this disease.
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CELL Stem Cell September 2, 2011

1-s2.0-S1934590911X00097-cov150hCELL Stem Cell. September 6th, 2011. In a recent issue of Cell Stem Cell, Luisa is reviewing the function of TET proteins in “The regulation of DNA methylation and stem cell differentiation”
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Cancer Cell July 11, 2011

S1535610811X00089_cov150hIn a recent Cover Article at Cancer Cell, Kelly and Linsey identify TET2, an enzyme regulating DNA methylation, as a novel tumor suppressor and regulator of stem cell self-renewal.
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Nature May 14, 2011

cover_nature473In a recent issue of Nature, we identify a novel tumour-suppressor function for the Notch pathway in myeloid leukaemia
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Cancer Cell September 14, 2010

S1535610810X00101_cov150hIn a recent issue of Cancer Cell, we identify CYLD and IKK as essential for the maintenance of T-ALL

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Nature Immunology August 11, 2010

homecoverIn a recent issue of Nature Immunology Jelena and Iannis discuss RNA-modifying proteins, Notch stability and T-cell leukemia.
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The Journal of Experimental medicine 12 May, 2010

thompsonIn an article at The Journal of Experimental Medicine Ben Thompson identifies the E3 ubiquitin ligase Fbw7 as a novel regulator of stem cell quiescence and self-renewal.
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Nature Immunology January 17, 2010

nature-immunologyIn a paper in Nature Immunology, our lab has uncovered an interaction between Fbw7 and c-myc as an essential regulator of stem cell differentiation.
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Nature June 18, 2010

natureIn a paper in Nature our lab identified the chemokine receptor CCR7 as a signal for the infiltration of leukemic cells into the CNS.
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Cell Stem Cell

cell-logoIn a paper published this week in CELL Stem Cell, Jie studied the role of the Hedgehog signaling pathway in the differentiation of Hematopoietic Stem Cells.
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Research and Clinical Interests 18 May, 2010

bioluminescenceOur laboratory studies the molecular mechanisms controlling hematopoietic stem cell (HSC) self-renewal, differentiation and transformation. More specifically we focus on the regulation of HSC cell cycle entry and on the effects of Notch signaling in stem cell differentiation. Finally, we study the role of the Notch pathway as an oncogenic trigger in acute lymphoblastic leukemia. Our goal is to design novel therapies that will target and suppress Notch transforming activity in vivo.