Welcome To Iannis Aifantis Lab
Our laboratory studies the molecular mechanisms driving normal stem cell differentiation and malignant transformation. More specifically, we are using the hematopoietic system as our model of study and focus on the genomic, epigenetic and proteomic regulation of hematopoietic stem cell differentiation and induction of leukemia and lymphoma. Our latest obsessions are diverse regulatory mechanisms including ubiquitin-regulated protein abundance, DNA and Histone methylation and the role of long non-coding RNAs in leukemia induction, progression and relapse after treatment. Finally, we are interested to visualize and measure the impact of tumor micro-environment on these regulatory mechanisms and test drugs that will target either the tumor or the tumor niche using both animal and human xenograft disease models.